The 15 Best Isekai Anime With an OP Main Character

The Best Isekai Anime With an OP Main Character Overlord Ainz Ooal Gown
Credit: Madhouse

The Best Isekai Anime With an OP Main Character Overlord Ainz Ooal Gown
Credit: Madhouse

Isekai is getting more prominent with every new season. It is an anime genre wherein the main character (MC) gets transported into a fantasy world and has to level up and gain experience. So, we’ve compiled a list of the 15 best isekai anime with an OP main character for your viewing pleasure!

RELATED: The Best Isekai Anime With Romance

  1. Arifureta: From Commonplace to World’s Strongest

    Arifureta: From Commonplace to World's Strongest follows Hajime Nagumo, who gets transported to the fantasy world of Tortus with his classmates.

    Nagumo's ability is low-level transmutation, while his classmates gain mystical powers.

    Nagumo is betrayed by one of his classmates on one upsetting day.

    Nagumo, feeling abandoned and distraught, embarks on a journey of vindication.

    He has grown cynical and ruthless, but among other things, he gained new skills and abilities.

    That isn't all. Nagumo also discovers a harem!

    RELATED: Who Does Hajime Nagumo End Up With in Arifureta?

  2. The Devil Is a Part-Timer!

    The Devil Is a Part-Timer! is a reverse isekai with an overpowered main character.

    It follows the demon lord Satan, who gets transported into modern-day Tokyo.

    Together with his demon general, Alciel, the demon lord was forced to retreat to a strange world where both of them needed to adapt to survive.

    The demon lord then decides to take on the identity of Sadao Maou. He applied to MgRonald's, where he eventually rose to the position of full-time Assistant Shift Manager.

    However, even in the real world, Maou encounters the hero Emilia in human form!

  3. Log Horizon

    Set in a universe where the online game world, Elder Tale, becomes the real world, 30,000 Japanese gamers, including the main character Shiroe, become trapped.

    Shiroe is known in the real world as Kei Shirogane, an Elder Tale veteran.

    Shiroe founded the Log Horizon guild to improve the adventurer city of Akiba on Elder Tale's Yamato server in order to adjust to the new world.

    Shiroe also gained the "Overskill" ability, which allows him to master Contract Art Ceremony.

    In short, he has the power to alter even the laws of the Elder Tale!

  4. Drifters

    Drifters is an isekai anime with historical and samurai elements.

    Shimazu Toyohisa is a Japanese samurai who is critically injured during the Battle of Sekigahara.

    Murasaki transports Toyohisa into an entirely new world after he walks out of the battlefield.

    Toyohisa joined the faction known as The Drifters. He discovered that he needed to fight alongside the other Drifters in order to defeat the Ends.

    These Ends are vigilantes who want to put an end to the Drifters and take over the world.

    They must stop the Ends with the help of his newfound comrade, the infamous warlord Nobunaga Oda, and the ancient archer Yoichi Suketaka Nasu, among others.

    RELATED: The Best Historical Anime to Watch

  5. Ascendance of a Bookworm

    Urano Motosu is reincarnated as a five-year-old commoner in Ehrenfest in Ascendance of a Bookworm.

    It is known that she died after being crushed by books during a real-world earthquake.

    Urano wishes to be reborn in a new world where she will be free to read books forever, just before she breathes her last.

    Reborn as Myne, she decides to write her own books in order to read again in a world where only the elite have access to books.

    As an added bonus, she gained some magical abilities! She has a large mana capacity that rivals that of the Archduke at such a young age.

    Myne is also skilled with blessings, a type of magic associated with words of prayer.

  6. That Time I Got Reincarnated as a Slime

    One of the most well-known isekai anime, That Time I Got Reincarnated as a Slime, tells the story of Satoru Mikami, a 37-year-old salaryman who is stabbed to death by an unknown assailant.

    He is reincarnated in a sword and sorcery world where he takes on the form of a slime monster.

    Reborn as Rimuru Tempest, he sets out to create his own monster nation with new allies.

    He also gained new skills and abilities, most notably the predator, which allows him to devour anything while mimicking skills and appearance.

  7. The Ones Within

    The Ones Within, also known as Naka no Hito Genome, follows Akatsuki Iride, who is transported into a F2P game called The Ones Within.

    Although there are rumors that players who successfully clear the game disappear, Akatsuki is completely unaware of this until he himself is transported!

    Akatsuki met the other successful players who were coerced to participate in clearing the stages of the game and retrieving the "chromosome" in the F2P game.

    Meanwhile, those who oppose the game's mechanics will be imprisoned in a "White Room."

    The good news is that Akatsuki specializes in escape and RPG games, which he can use to help clear the games.

  8. The Rising of the Shield Hero

    The return of The Rising of the Shield Hero Season 2 sees Naofumi Iwatani defeating the Spirit Tortoise and preventing the mysterious Waves of Calamity from destroying the world.

    Originally, Naofumi was a reclusive gamer who was summoned as a shield hero by the King of Melromarc. It turns out that there are other heroes besides Naofumi.

    While obtaining the shield, Naofumi surpassed the other cardinal heroes in strength.

    After being expelled by the king, Naofumi decides to train on his own and purchase cheap slaves from a merchant.

    He discovers that there is more to it than just the shield, contrary to everyone's belief.

  9. Wise Man’s Grandchild

    Wise Man's Grandchild, also known as Kenja no Mago, follows the sage hero Shin Wolford, who possesses powerful magical abilities but lacks common sense.

    The young salaryman is reincarnated as a helpless infant after dying in a truck accident in the real world.

    Fortunately, Shin was taken under the wing of the sage hero, Merlin Wolford.

    Merlin, along with Melida Bowen and Michel Collins, fed Shin all of their knowledge and powers while failing to teach common sense!

    Shin enters the Magic Academy of the King of Erlshide Kingdom at the age of 15 with the understanding that he will not be used for political warfare.

    Eventually, Shin's powers and abilities extend beyond the S-rank. He has the ability to create gears of the National Treasure level.

    He can also cast spells without using words.

    READ MORE: The Best Fantasy Anime You Should Watch

  10. How Not to Summon a Demon Lord

    How Not to Summon a Demon Lord follows Takuma Sakamoto, a regular guy who gets isekai'd in his favorite MMORPG game, Cross Reverie.

    Takuma takes on the role of his character, the Demon Lord Diablo, in the game.

    Diablo was summoned by the pantherian Rem and the elf Shera in an attempt to make him a slave.

    However, the situation worked against them, turning Rem and Shera into Diablo's slaves instead.

    Diablo adjusts to his new life in the MMORPG world using his veteran skills as a Cross Reverie player.

  11. Overlord

    In Overlord, Ainz Ooal Gown, formerly known as Momonga, leads his guild alongside his overly powerful floor guardians in Nazarick.

    When the YGGDRASIL server went down, the player known as Momonga became trapped in the new world.

    With no other means to log out of the game, Momonga decides to protect his own guild from various threats for the sake of his people.

    He is now known as Ainz Ooal Gown, and his goal is to find other players who are also stuck in the game while adjusting to his new life in Nazarick.

    Ainz Ooal Gown is a force to be reckoned with among humans and other creatures alike, with his power level at its peak and a plethora of magical spells at his disposal.

    READ MORE: Could Overlord's Ainz Ooal Gown Beat Goku?

  12. The Eminence in Shadow

    Due to an unfortunate accident in the real world, a young man named Minoru Kagenou is isekai'd in a magical world where he aims to become a power in the shadows by utilizing his vast knowledge of martial arts and training disciplines.

    Cid has always admired the heroes who work in the shadows since he was a child.

    Unlike other boys who aspire to be protagonists or final bosses, Cid prefers to be known as a minor character who reveals himself as the mastermind at the very end.

    Cid tries to recruit new members to his shady organization in the new world, hoping to finally live up to his dreams.

    As it turns out, there are actual evil threats that Cid and his team must eliminate at all costs!

    READ MORE: The Eminence in Shadow: Who Knows that Cid Is Shadow?

  13. Reincarnated as a Sword

    In this isekai anime, the nameless protagonist got into an unfortunate accident in the real world.

    As a result, he got reincarnated as a sword in a fantasy world, unlike the other people on this list who share the same fate.

    The sword, on the other hand, has evolved into an intelligent sentient weapon capable of acquiring skills and power-ups simply by killing goblins, dragons, or even final bosses.

    Now that the sword has grown in strength, he must seek out a wielder who will put his powers and abilities to the test.

    When the sword meets Fran, the two agree to collaborate in order to find a way for Fran to evolve and become a much stronger sword wielder.

    READ MORE: Does Fran Evolve in Reincarnated as a Sword?

  14. Harem in the Labyrinth of Another World

    Michio Kaga, a struggling young man, goes online and discovers a strange website that asks a lot of questions and uses a point-based system to allow him to create skills and abilities for a character.

    He reads from a prompt after answering all of the website's questions. Then, he is finally allowed to be transported into another world with the same settings he chose for his character.

    Furthermore, the prompt states that once he accepts, there is no turning back.

    Michio then accepts the prompt without thinking much about it, and he finds himself in another world!

    His life in the Other World has never been more interesting, as he has been able to gain strength at a faster rate while also claiming idol-level girls.

  15. Parallel World Pharmacy

    In this medical-themed isekai anime, pharmacologist Kanji Yukitani dies from overwork in the real world, only to be reincarnated as an apprentice to the Royal Court Pharmacist in the medieval world.

    The 10-year-old boy, now known as Farma de Medicis, was given inhuman abilities to see through various diseases, material creation, and material destruction.

    Farma uses his previous professional experience and knowledge to create innovative medicines that few people, including his own father, are unaware of.

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